Dr. Neil E. Klepeis is currently a Consulting Assistant Professor in the Department of Civil & Environmental Engineering at Stanford University (Stanford, CA USA). He is also a Senior Research Affiliate at ETR Associates (Scotts Valley, CA) and an Adjunct Assistant Professor at San Diego State University.
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As a young scientist, Neil Klepeis was trained as a physical and theoretical chemist at Colgate University (BA degree) and Stanford University (MS degree). He has done research on molecular structure elucidation using electron diffraction and on the characterization of molecular vibrational energies using quantum chemistry.
Subsequent to his work in basic chemistry, Dr. Klepeis became interested in environmental science, receiving a Ph.D. in environmental health from the University of California at Berkeley in 2004. His Ph.D. work was focused on the study of indoor air pollutant dynamics and human exposure through computer simulation and controlled chamber experiments.
In addition to his modeling work, Dr. Klepeis has performed several tobacco smoke air pollution monitoring studies, including a recent study on outdoor tobacco smoke. Since he began working in the exposure field in 1993, he has published many articles and reports on the nature of tobacco smoke exposure.
Dr. Klepeis has wide-ranging interests in applied science directed at improving human health. His research seeks to elucidate the physical and social mechanisms by which exposure to specific health risks can be reduced or eliminated.
Specific areas of interest include:
Ph.D., 2004, Environmental Health Sciences, University of California at Berkeley, Dissertation: "Using Computer Simulation to Explore Multi-Compartment Effects and Mitigation Strategies for Exposure to Residential Secondhand Tobacco Smoke" (William W. Nazaroff, advisor in Civil and Environmental Engineering).
M.S., 1992, Chemistry, Stanford University (Wesley D. Allen, advisor in Quantum Chemistry).
B.A., 1989, Chemistry, Colgate University, Magna Cum Laude (Quang Shen, advisor in Physical Chemistry).
Consulting Assistant Professor; 2006-present; Stanford University, Stanford, CA, Dept. of Civil & Environmental Engineering; Co-Investigator on Projects: "Human Exposure Analysis for Pollutants from Secondhand Smoke" and "Exposure to Secondhand Smoke: Effects of Proximity"; Grants Awarded from the Flight Attendant Medical Research Institute (FAMRI) and the Tobacco Related Disease Research Program (TRDRP); Lynn Hildeman, PI; Wayne Ott and James Repace, Co-Investigators.
Senior Researcher; 2005-present; ETR Associates, Scotts Valley, CA; Innovative Computer-Aided Behavioral Interventions; PI on Project: "Computer Simulation as a Tool for Reducing or Eliminating Secondhand Tobacco Smoke Exposure"; Grants awarded from Tobacco Related Disease Research Program (TRDRP) of California and the National Institutes of Health (NIH); Pamela Drake, Co-Investigator.
Adjunct Assistant Professor; 2007-present; San Diego State University, Graduate School of Public Health; PI on Project: "Real-Time Secondhand Smoke Feedback as a Catalyst for Smoke Free Homes"; Co-investigators: Melbourne Hovell and Suzanne Hughes.
Post-Doctoral Researcher; 2004-2006; Stanford University, Stanford, CA, Dept. of Statistics; Project: "Quantifying Human Exposure to Secondhand Smoke"; Grants Awarded from: California Department of Health Services Tobacco Control Section and the Flight Attendant Medical Research Association (FAMRI), Paul Switzer, Principal Investigator; Wayne Ott, Co-investigator.
Graduate Researcher; 2003; Center for Exposure and Health Tracking, University of California at Berkeley, Center for Occupational and Environmental Health, School of Public Health.
PhD Student; 1997-2004; University of California at Berkeley, William W. Nazaroff, advisor.
Graduate Researcher; 1997-2002; Lawrence Berkeley National Laboratory, Indoor Environment Department, EPA University Partnership Project: "Multi-Domain Framework for Integrating Models and Measurements of Multimedia Environmental Contaminants," Thomas McKone, Principal Investigator; Haluk Ozkaynak, EPA Project Director.
Independent Consultant; 1997-2001; Stanford University Award, Dept. of Statistics; Grant Awarded from: Tobacco Related Disease Research Program of California (TRDRP); Paul Switzer, Principal Investigator; Wayne Ott, Co-investigator.
Graduate Researcher; 1997-1998; Center for Occupational and Environmental Health, University of California at Berkeley; S. Katharine Hammond, Supervisor.
Senior Scientist; 1995-1997; Lockheed Martin, Las Vegas, NV; Technical and Research Support for EPA Activity Pattern and Exposure Modeling Projects, Steve Hern, EPA Project Director; William Engelmann, EPA Project Manager.
Project Manager; 1994-1995; Information Systems and Services, Inc., Las Vegas, NV; Technical and Research Support for EPA Activity Pattern and Exposure Modeling Projects, Niren Nagda, Project Director; Steve Hern, EPA Project Director; Joseph Behar, EPA Project Manager.
Research Consultant; 1993-1994; Stanford University, Dept. of Statistics; Grant Awarded from: Tobacco Related Disease Research Program of California (TRDRP); Paul Switzer, Principal Investigator; Wayne Ott, Co-investigator.
Graduate Researcher; 1989-1991; Stanford University, Department of Chemistry.
Undergraduate Researcher; 1986-1989; Colgate University, Department of Chemistry.
Director; Exposure Analysis Workbook Project: Developing a Web-based Exposure Science Curriculum; Stanford University, Dept. of Civil and Environmental Engineering, Stanford, CA; 2007-present.
Invited Speaker; California Department of Health Services, Tobacco Control Section, Conference: Smoke-Free California: Where We Live, Work, and Play, "Monitoring Airborne Levels of Outdoor and In-Vehicle Secondhand Tobacco Smoke," May 16, 2006.
Invited Speaker; Ontario Tobacco Research Unit, University of Toronto in Collaboration with the Centre for Addiction and Mental Health; Workshop on Biological and Atmospheric Measurement of Tobacco Use and Exposure in Transdisciplinary Research; Dr. Roberta Ferrence, host; "Comparing Methods for the Real-Time Measurement of Secondhand Tobacco Smoke Particles," May 19-20, 2005.
Invited Speaker; Air Quality Group Seminar, Department of Civil and Environmental Engineering, Stanford University; Lynn Hildemann, host; "Measuring Proximate Exposure to Sources of Air Pollution in Outdoor Microenvironments"; February 8, 2005.
Invited Speaker; Environmental Energy Technologies Division Seminar, Lawrence Berkeley National Laboratory, Berkeley, CA; Brett Singer, host; "Using Mathematical Models in Public Health: The Case of Residential Exposure to Secondhand Tobacco Smoke"; November 11, 2004
Invited Lecturer; "Environmental Health Seminar, ENVH 580"; L.-J. Sally Liu, Instructor; University of Washington Department of Environmental Health; June 2004.
Invited Lecturer; "Exposure Assessment"; James Leckie, Instructor; Stanford University Dept. of Civil and Environmental Engineering; Fall 2002.
Graduate Student Instructor; "Introduction to Environmental Health Sciences"; Kirk Smith, Instructor; University of California at Berkeley School of Public Health; Fall 2000.
Invited Lecturer; "Exposure Assessment"; James Leckie, Instructor; Stanford University Dept. of Civil and Environmental Engineering; Fall 1997.
Instructor; "Introduction to the BASIC Computer Language"; Las Vegas Community College; Fall 1996.
Graduate Student Instructor; "Physical Chemistry" ; Wesley D. Allen, Instructor, Stanford University Dept. of Chemistry, Fall 1990.
Graduate Student Instructor; "Introduction to Chemistry"; Stanford University Dept. of Chemistry; Fall 1989.
International Society of Exposure Analysis, 1995
American Chemical Society, 1997
Haskell-Shiff Memorial Award Colgate University (most promising student in Physical Chemistry), 1986
Phi Beta Kappa, 1989
Reviewer for the U.S. EPA's "Exposure Factors Handbook," 1995
Reviewer of US Surgeon General's report "The Health Consequences of Involuntary Exposure to Tobacco Smoke," 2004
Referee for scientific journals, 1997-2007:
Cheng KC, Jiang RT, Acevedo-Bolton V, Ott WR, Klepeis NE, Hildemann LA (2010) Model-Based Reconstruction of the Time Response of Electrochemical Air Pollutant Monitors to Rapidly Varying Concentrations. Journal of Environmental Monitoring 12: 846 - 853, DOI: 10.1039/b921806h.
[Journal Link]
Jiang RT, Cheng KC, Acevedo-Bolton V, Klepeis NE, Repace JL, Ott WR, Hildemann LA (2010). Measurement of Fine Particle Concentrations and Smoking Activity in a Statewide Survey of 36 California Indian Casinos. Journal of Exposure Science and Environmental Epidemiology. doi: 10.1038/jes.2009.75.
[Journal Link]
Klepeis NE, Gabel EB, Ott WR, Switzer P (2009) Outdoor Air Pollution in Close Proximity to a Continuous Point Source. Atmospheric Environment, 43(20): 3155-3167.
[Journal Link]
Ferro AR, Klepeis NE, Ott WR, Nazaroff WW, Hildemann LM, Switzer P (2009). Effect of interior door position on room-to-room differences in residential pollutant concentrations after short-term releases. Atmospheric Environment, 43(3): 706-714.
[Journal Link]
Ott WR, Klepeis NE, Switzer P (2008) Air change rates of motor vehicles and in-vehicle pollutant concentrations from secondhand smoke. Journal of Exposure Science and Environmental Epidemiology. 18:312–325.
[Reprint] [Journal Link].
Klepeis NE, Ott WR, Switzer P (2007) Real-time measurement of outdoor tobacco smoke particles. Journal of the Air and Waste Management Association, 57:522-534.
[Preprint]. [Journal Link].
Klepeis NE and Nazaroff WW (2006) Modeling residential exposure to secondhand tobacco smoke. Atmospheric Environment 40(23):4393-4407.
[Journal Link]. [PostPrint].
Klepeis NE and Nazaroff WW (2006) Mitigating residential exposure to secondhand tobacco smoke. Atmospheric Environment 40(23):4408-4422.
[Journal Link]. [PostPrint].
Ott WR, Klepeis NE, Switzer P (2003) Analytical solutions to compartmental indoor air quality models with application to environmental tobacco smoke concentrations measured in a house. Journal of the Air and Waste Management Association 53:918-936.
[Preprint]. [Journal Link].
Klepeis NE, Apte MG, Gundel LA, Sextro RG, Nazaroff WW (2003) Determining size-specific emission factors for environmental tobacco smoke particles. Aerosol Science & Technology 37(10): 780-790.
[Journal Link].
Klepeis NE, Nelson WC, Ott WR, Robinson J, Tsang AM, Switzer P, Behar JV, Hern S; Engelmann W (2001). The national human activity pattern survey (NHAPS): A resource for assessing exposure to environmental pollutants. Journal of Exposure Analysis and Environmental Epidemiology 11(3):231-252.
[Journal PDF].
Klepeis NE, Ott WR; Repace JL (1999) The effect of cigar smoking on indoor levels of carbon monoxide and particles. Journal of Exposure Analysis and Environmental Epidemiology 9(6): 622-635.
[Journal PDF].
Klepeis NE (1999) Validity of the uniform mixing assumption: determining human exposure to environmental tobacco smoke. Environmental Health Perspectives 107(Supp2): 357-363.
[Journal Link].
Klepeis NE (1999) An introduction to the indirect assessment approach: modeling human exposure using microenvironmental measurements and the recent national human activity pattern survey. Environmental Health Perspectives 107(Supp2): 365-374.
[Journal Link].
Klepeis NE, Ott WR; Switzer P. (1996) A multiple-smoker model for predicting indoor air quality in public lounges. Environmental Science and Technology, 30(9): 2813-2820.
[Journal Link].
Klepeis NE, East ALL, Csaszar AG, Allen WD, Lee TJ; Schwenke DW (1993) The [FHCl]- molecular anion - structural aspects, global surface, and vibrational eigenspectrum. Journal of Chemical Physics 99(5):3865-3897.
[Journal PDF].
Ott WR, Klepeis NE, Rozenberg D, Switzer P. "Evaluation of an Indoor-Outdoor Air Quality Model Using Continuous Measurements of Particulate PAH in Several Homes," 2006.
Klepeis NE, Ott WR, Switzer P. "Measuring Outdoor Concentrations of Secondhand Tobacco Smoke Particles," 2006.
Klepeis NE, Ott WR, Switzer P. "Quantifying Proximate Exposure to Sources of Outdoor and Indoor Air Pollution," 2006.
Ferro AR, Klepeis NE, Ott WR, Switzer P, Nazaroff WW, Hildemann L. "Measuring the Effect of Door and Window Position on Multi-Room Air Pollutant Concentrations in Residences," 2006
Ott WR, Klepeis NE, Switzer P. "Measurement of Environmental Tobacco Smoke Concentrations Inside Automobiles," 2006.
Klepeis NE, Switzer P, Ott WR. "An Averaging-Time Model for Ambient Particulate Matter Concentrations," 2006.
Klepeis NE "Modeling Human Exposure to Air Pollution," In: Exposure Analysis, edited by Wayne R. Ott, Lance A. Wallace, and Anne Steinemann, CRC Press, Boca Raton, 2006.
Nazaroff WW and Klepeis NE "Environmental Tobacco Smoke Particles," In: Indoor Environment: Airborne Particles and Settled Dust, edited by Lidia Morawska and Tunga Salthammer, Wiley-VCH, Weinheim, October 2003.
Repace JL, Ott WR, and Klepeis NE. "Indoor Air Pollution from Cigar Smoke," In: Cigars: Health Effects and Trends, Smoking and Tobacco Control Monograph No. 9, edited by Donald R. Shopland, National Cancer Institute, National Institutes of Health, February 1998.
Klepeis NE, Ott WR, Switzer P. "Real-Time Monitoring of Outdoor Environmental Tobacco Smoke Concentrations: A Pilot Study," Technical Report, Department of Statistics, Stanford University, Stanford, CA, Contract No. 3317SC, University of California at San Francisco, Prepared for the State of California, Tobacco Control Section, Sacramento, CA, March 2004.
Klepeis NE, Switzer P, and Ott WR. "Estimating Potential Exposure to Environmental Tobacco Smoke Particles Using 24-Hour Recall Diaries from Three Human Activity Pattern Surveys Conducted on California Populations," Tobacco-Related Disease Research Program of the State of California (University of California), Grant No. 6RT-0118, Department of Statistics, Stanford University, Stanford, CA, 2001.
Klepeis NE, Ott WR, and Switzer P. "Determining Parameters of a Two-Compartment Indoor Air Quality Model From Experimental Data: Computer Optimization Using a Grid Search Method," Tobacco-Related Disease Research Program of the State of California (University of California), Grant No. 6RT-0118, Department of Statistics, Stanford University, Stanford, CA, 2001.
Tsang, A.M. and N.E. Klepeis "Three Telephone Surveys of Human Activity Patterns in California: The 1992-94 National Human Activity Pattern Survey; the 1987-88 California Activity Pattern Survey of Adults and Youth; and the 1989-90 California Activity Pattern Survey of Children," Draft Technical Report, US EPA, Washington D. C., 1998.
Klepeis, N.E., A.M. Tsang and J.V. Behar. "Analysis of the National Human Activity Pattern Survey (NHAPS) Responses from a Standpoint of Exposure Assessment." Technical Report, EPA/600/R-96/074, US EPA, Washington D. C., 1996.
Tsang, A.M. and N.E. Klepeis. "A Detailed Analysis of the National Human Activity Pattern Survey (NHAPS) Respondents." Technical Report, EPA/600/R-96/148, US EPA, Washington D. C., 1996.
Klepeis, N.E. "User's and Programmer's Manual for the Total Human Exposure Model (THEM), Version 1.0.," Technical Report, Stanford University, 1994.
Klepeis NE, Ott WR, Wallace LA, Repace JL, Switzer P. Poster Presentation: "Interrelating and Evaluating Real-Time Airborne Particle Monitors", Joint Meeting of the International Society of Exposure Analysis (ISEA) and the International Society of Environmental Epidemiology (ISEE); Paris, France; September 2006.
Switzer P, Klepeis NE, Ott WR. Oral Presentation and First Prize in Poster Contest: "Quantifying Human Exposure to Secondhand Tobacco Smoke," 5th Annual Flight Attendant Medical Research Institute (FAMRI) Scientific Symposium, Cambridge, MA, May 2006.
Ott WR, Klepeis NE, Switzer P. "Measuring and Modeling Exposure to Secondhand Smoke In Vehicles," Presentation at the 15th International Society of Exposure Analysis (ISEA) Annual Conference, Tuscon, AZ, October 30-November 3, 2005.
Switzer P, Ott WR, Klepeis NE. Poster Presentation: "Quantifying Human Exposure to Secondhand Tobacco Smoke," 4th Annual Flight Attendant Medical Institute (FAMRI) Scientific Symposium, Miami, FL, May 2005.
Klepeis NE, Ott WR, and Switzer P. "Human Exposure to Outdoor Secondhand Tobacco Smoke," Poster presentation at the 14th International Society of Exposure Analysis (ISEA) Annual Conference, Philadelphia, PA, October 17-21, 2004.
Ott WR, Klepeis NE, Rozenberg D, and Switzer P. "Continuous Measurements of Indoor-Outdoor Particular Polycyclic Aromatic Hydrocarbon (PPAH) Concentrations in Seven Homes with Application to Indoor Mass-Balance Model Parameters and Prediction Error," Platform presentation at the 14th International Society of Exposure Analysis (ISEA) Annual Conference, Philadelphia, PA, October 17-21, 2004.
Klepeis NE, Switzer P, Ott WR. "Development of Averaging Time Models for Particulate Air Pollutants," Poster presentation at ISEA/ISEE Joint Conference, Vancouver, BC, August 11-15 2002.
Klepeis NE and Nazaroff WW. "Characterizing Size-Specific Environmental Tobacco Smoke Particle Emissions," 9th Annual Conference on Indoor Air Quality and Climate, Indoor Air 2002, Monterey, CA, June 30-July 5, 2002.
Klepeis, NE and Nazaroff WW. "Determining Size-Resolved Particle Emission Profiles for Sources of Environmental Tobacco Smoke," PM-2000: Particulate Matter and Health, The Scientific Basis for Regulatory Decision-Making Specialty Conference and Exhibition. Charleston, SC, January 24, 2000.
Klepeis, NE and Nazaroff WW. "Simulating Indoor Concentrations of Size-Resolved Particles: Emission Factors and Deposition Rates for ETS," 10th Annual Conference of the International Society of Exposure Analysis. October 24, 2000.
Repace, J.L., W.R. Ott and N.E. Klepeis. "Mathematical Models for Predicting Indoor Environmental Tobacco Smoke (ETS) Concentrations: A Review." 10th Annual Conference of the International Society of Exposure Analysis. October 24, 2000.
Ott, W., P. Switzer and N. Klepeis. "Determining Particle Emission Source Strengths for Common Residential Indoor Sources Using Real-Time Measurements and Piecewise Continuous Solutions to the Mass Balance Equation." 10th Annual Conference of the International Society of Exposure Analysis. October 24, 2000.
Ott, W., P. Switzer and N. Klepeis. "Relationship Between Observed Fireplace Plume Activity in Residential Neighborhoods and Indoor-Outdoor Real-Time Particulate Aromatic Hydrocarbon (PPAH) Concentrations." 10th Annual Conference of the International Society of Exposure Analysis. October 24, 2000.
Ott, W., L. Wallace, N. Klepeis, P. Switzer, D. Mage and P. Lioy. "Research Directions in Predicting Personal Exposure Distributions to Particles (PM-10) Using a Random Component Superposition (RCS) Model." 10th Annual Conference of the International Society of Exposure Analysis. October, 24, 2000.
Klepeis, N., M. Apte, L. Gundel, W. Nazaroff and R. Sextro. "Characterizing ETS Emissions From Cigars: Chamber Measurements of Nicotine, Particle Mass, and Particle Size." Proceeding of the 8th International Conference on Indoor Air Quality and Climate -- Indoor Air '99, 1999.
Klepeis, N., W. Ott, P. Switzer, M. Zelenka, A. Huber and W. Nelson. "Air Pollutant Time Series Analysis: Outdoor Sources of Carbon Monoxide and Polycyclic Aromatic Hydrocarbons." Joint Meeting of the Society for Risk Analysis and the International Society of Exposure Analysis. New Orleans, August 12, 1996.
Klepeis, N., W. Ott, P. Switzer, M. Zelenka, A. Huber and W. Nelson. "Optimization of a Real-Time Indoor-Outdoor Air Quality Model of Carbon Monoxide and Polycyclic Aromatic Hydrocarbons." Joint Meeting of the Society for Risk Analysis and the International Society of Exposure Analysis. New Orleans, August 12, 1996.
Klepeis, N.E., W.R. Ott, and P. Switzer. "Total Human Exposure Model (THEM) for Respirable Suspended Particles (RSP)." Paper Presented at the 87th Annual Meeting of the Air and Waste Management Association: Cincinnati, OH, June 19, 1994.
Ott, W.R., N. Wilson, N.E. Klepeis and P. Switzer. "Real-time Monitoring of Polycyclic Aromatic Hydrocarbons and Respirable Suspended Particles from Environmental Tobacco Smoke in a Home." Paper Presented at the Air and Waste Management Symposium on Measurement of Toxic and Related Air Pollutants: Durham, NC, May 2-6, 1994.
Doctoral Dissertation: "Using Computer Simulation to Explore Multi-Compartment Effects and Mitigation Strategies for Residential Exposure to Secondhand Tobacco Smoke," University of California at Berkeley, 2004.
Masters Thesis: "The Potential Energy Surface and Vibrational Eigenspectrum of the FHCl- Molecular Anion," Stanford University, 1992.
Undergraduate Thesis, with high honors: "Using Computers to Aid in the Elucidation of Molecular Structure and Conformation Through the Phenomenon of Electron Diffraction," Colgate University, 1989.
"A Software Package for Human Exposure Research Implemented in the R Language." 2002-Present.
"A Total Human Exposure Model for Particles," 1994.